Right - C0 trapdoor space is in the 24-bit address area that is reachable from Z2 slots, so yes, you should turn that off,
The MapROM part is also not desirable for OS3.2.1, as you most likely want the Kickstart to be mapped in Fastmem. However, soft-kicking is not possible with BigRam2630 due to the limitation that the lower 64k (again, if I remember right) need to be binary-identical with the physical ROM. You may be better off using the MMU to map a new ROM.
It's only updating select libraries and not doing a full soft kick, so it seems to be happy. I don't actually want maprom and already use MuLibs to remap the ROM to fast memory, but when I didn't have it on, it started dropping my SCSI controller when rebooting for LoadModule. It's probably the documented issue that I need another Zorro card in between the A2630 and my SCSI controller, but I don't have one to put in there right now.