So I have an ACA500Plus, which I could never get to clock beyond 21 MHz and still have it boot. To that I have attached a ACA1221lc. I have that over-clocked to 40 MHz ( SysInfo claims it's running at 44 MHz ). The other thing I had to add to get this to work reliably was a CA-PSU. The Stock one I have on my 500+ just didn't work well overclocked.
So I've ran some process intensive math programs I have in Amiga Basic and some demos. Running for a couple hours. It works fine. Doesn't even get that hot to the touch. I was thinking I might have to add a fan, but that may not even be needed.
As a side note, AmigaBasic is slow. The math programs I also have versions for 8-bit CBM basic, and the Amiga at 40+ MHz is only around 3 times faster than a Plus/4. Which seems pretty crazy. I'll have to re-write them in C...